hypogonadotropic hypogonadism 21 with or without anosmia
Findings
No curated finding names hypogonadotropic hypogonadism 21 with or without anosmia yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Any hypogonadotropic hypogonadism in which the cause of the disease is a mutation in the FLRT3 gene.
Definition from the Mondo Disease Ontology (MONDO:0014107), read 2026-09-29. CC BY 4.0.
- Inheritance
- Autosomal dominant inheritance · Oligogenic inheritance
- Onset and course
- Juvenile onset
HPO, annotations 2026-09-02
Features
6 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Cleft lipHPOHP:0410030
- Delayed pubertyHPOHP:0000823
- Hearing impairmentHPOHP:0000365
- HyposmiaHPOHP:0004409
- OsteopeniaHPOHP:0000938
- OsteoporosisHPOHP:0000939
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- FLRT3HGNC:3762
- Limited · Ambry Genetics · Autosomal dominant · 2020
- Limited · Labcorp Genetics (formerly Invitae) · Unknown · 2017
- Limited · PanelApp Australia · Autosomal dominant · 2025
Where it sits
- A kind of
Other names
3 names
Resolves to: hypogonadotropic hypogonadism 21 with or without anosmia
- Also called
- FLRT3 hypogonadotropic hypogonadismhypogonadotropic hypogonadism 21 with anosmiahypogonadotropic hypogonadism caused by mutation in FLRT3