hyperacute transplant rejection
Findings
No curated finding names hyperacute transplant rejection yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A transplant rejection that appears in the first minutes following transplantation and occurs only in vascularized grafts. This very fast rejection is characterized by vessels thrombosis leading to graft necrosis. Hyperacute rejection is caused by the presence of antidonor antibodies existing in the recipient before transplantation. These antibodies induce both complement activation and stimulation of endothelial cells to secrete Von Willebrand procoagulant factor, resulting in platelet adhesion and aggregation. The result of these series of reactions is the generation of intravascular thrombosis leading to lesion formation and ultimately to graft loss.
Definition from the Mondo Disease Ontology (MONDO:1010186), read 2026-09-29. CC BY 4.0.
Where it sits
- A kind of