hydrops-lactic acidosis-sideroblastic anemia-multisystemic failure syndrome
MONDO:0014869Mondo
Findings
No curated finding names hydrops-lactic acidosis-sideroblastic anemia-multisystemic failure syndrome yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
- Inheritance
- Autosomal recessive inheritance
- Onset and course
- Antenatal onset
HPO, annotations 2026-09-02
Features
22 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- AnemiaHPOHP:0001903
- 1 of 1 reported patient
- AscitesHPOHP:0001541
- 1 of 1 reported patient
- Decreased liver functionHPOHP:0001410
- 1 of 1 reported patient
- Erythroid hyperplasiaHPOHP:0012132
- 1 of 1 reported patient
- Extramedullary hematopoiesisHPOHP:0001978
- 1 of 1 reported patient
- Fetal pericardial effusionHPOHP:0025671
- 1 of 1 reported patient
- HematuriaHPOHP:0000790
- 1 of 1 reported patient
- HypoalbuminemiaHPOHP:0003073
- 1 of 1 reported patient
- Increased circulating lactate concentrationHPOHP:0002151
- 1 of 1 reported patient
- Increased mean corpuscular volumeHPOHP:0005518
- 1 of 1 reported patient
- Intrauterine growth retardationHPOHP:0001511
- 1 of 1 reported patient
- Lactic acidosisHPOHP:0003128
- 1 of 1 reported patient
Show the remaining 10
- Metabolic acidosisHPOHP:0001942
- 1 of 1 reported patient
- Nonimmune hydrops fetalisHPOHP:0001790
- 1 of 1 reported patient
- OligohydramniosHPOHP:0001562
- 1 of 1 reported patient
- Overriding aortaHPOHP:0002623
- 1 of 1 reported patient
- Patent ductus arteriosusHPOHP:0001643
- 1 of 1 reported patient
- Pulmonary arterial hypertensionHPOHP:0002092
- 1 of 1 reported patient
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- LARS2HGNC:17095
- Strong · Labcorp Genetics (formerly Invitae) · Autosomal recessive · 2020
- Strong · PanelApp Australia · Autosomal recessive · 2025
- Limited · Ambry Genetics · Autosomal recessive · 2020
Where it sits
Other names
3 names
Resolves to: hydrops-lactic acidosis-sideroblastic anemia-multisystemic failure syndrome
- Also called
- HLASAhydrops, lactic acidosis, and sideroblastic anaemiahydrops, lactic acidosis, and sideroblastic anemia