human African trypanosomiasis
Findings
No curated finding names human African trypanosomiasis yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A parasitic disorder caused by protozoa of the Trypanosoma brucei species. It is transmitted by flies and is endemic in various regions of Sub-Saharan Africa. Signs and symptoms include fever, joint pain, headache, and significant swelling of the lymph nodes. If left untreated, the parasitic infection causes anemia, heart, kidney, and endocrine failure, and neurologic damage. Subsequently patients develop confusion, disruption of the sleep cycle, and mental deterioration. The infection may lead to coma and death.
Definition from the Mondo Disease Ontology (MONDO:0005459), read 2026-09-29. CC BY 4.0.
- Onset and course
- Miscarriage
HPO, annotations 2026-09-02
Features
86 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Abnormality of the nervous systemHPOHP:0000707
- Very frequent (80% to 99% of cases)
- CataplexyHPOHP:0002524
- Very frequent (80% to 99% of cases)
- Excessive daytime somnolenceHPOHP:0001262
- Very frequent (80% to 99% of cases)
- Periodic feverHPOHP:0032323
- Very frequent (80% to 99% of cases)
- Sleep disturbanceHPOHP:0002360
- Very frequent (80% to 99% of cases)
- Sleep-wake cycle disturbanceHPOHP:0006979
- Very frequent (80% to 99% of cases)
Show the remaining 74
- Brain imaging abnormalityHPOHP:0410263
- Frequent (30% to 79% of cases)
- FatigueHPOHP:0012378
- Frequent (30% to 79% of cases)
- Gait disturbanceHPOHP:0001288
- Occasional (5% to 29% of cases)
- Frequent (30% to 79% of cases)
- HeadacheHPO · MondoHP:0002315
- Frequent (30% to 79% of cases)
- HepatomegalyHPOHP:0002240
- Frequent (30% to 79% of cases)
- HepatosplenomegalyHPOHP:0001433
- Frequent (30% to 79% of cases)
Where it sits
- A kind of
- Narrower terms (2)
Other names
3 names
Resolves to: human African trypanosomiasis
- Also called
- Africam sleeping sicknessAfrican trypanosomiasissleeping sickness