Holmes-Adie syndrome
MONDO:0018690Mondo
Findings
No curated finding names Holmes-Adie syndrome yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A rare syndrome characterized by an abnormally dilated pupil, hypoflexia, and diaphoresis. The syndrome is usually caused by a viral or bacterial infection. The abnormally dilated pupil is caused by damage to postganglionic parasympathetic fibers innervating the eye.
Definition from the Mondo Disease Ontology (MONDO:0018690), read 2026-09-29. CC BY 4.0.
Features
11 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Tonic pupilHPOHP:0012074
- Very frequent (80% to 99% of cases)
- Abnormal pupillary light reflexHPOHP:0007695
- Frequent (30% to 79% of cases)
- AnisocoriaHPOHP:0009916
- Frequent (30% to 79% of cases)
- AreflexiaHPOHP:0001284
- Frequent (30% to 79% of cases)
- Blurred visionHPOHP:0000622
- Frequent (30% to 79% of cases)
- MydriasisHPOHP:0011499
- Frequent (30% to 79% of cases)
- AnisometropiaHPOHP:0012803
- Occasional (5% to 29% of cases)
- Chronic coughHPOHP:0034315
- Occasional (5% to 29% of cases)
- HypermetropiaHPOHP:0000540
- Occasional (5% to 29% of cases)
- Orthostatic hypotensionHPOHP:0001278
- Occasional (5% to 29% of cases)
- PhotophobiaHPOHP:0000613
- Occasional (5% to 29% of cases)
Where it sits
- A kind of
Other names
5 names
Resolves to: Holmes-Adie syndrome
- Also called
- Adie pupilAdie SyndromeAdie's pupiltonic pupiltonic pupil-tendon areflexia syndrome