herpes simplex encephalitis, susceptibility to, 4
Findings
No curated finding names herpes simplex encephalitis, susceptibility to, 4 yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A Mendelian susceptibility or predisposition to herpes simplex infection induced encephalitis in which the cause of the diseas is a mutation in the TICAM1 gene.
Definition from the Mondo Disease Ontology (MONDO:0013921), read 2026-09-29. CC BY 4.0.
- Inheritance
- Autosomal dominant inheritance · Autosomal recessive inheritance · Typified by incomplete penetrance
- Onset and course
- Childhood onset
HPO, annotations 2026-09-02
Features
2 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- HSV encephalitisHPOHP:0012302
- 3 of 5 reported patients
- 2 of 2 reported patients · Late onset
- Recurrent aphthous stomatitisHPOHP:0011107
- 3 of 5 reported patients
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- TICAM1HGNC:18348
- Strong · Labcorp Genetics (formerly Invitae) · Autosomal recessive · 2019
- Strong · PanelApp Australia · Autosomal dominant · 2025
- Strong · PanelApp Australia · Autosomal recessive · 2025
- Limited · Ambry Genetics · Semidominant · 2018
- Limited · Labcorp Genetics (formerly Invitae) · Autosomal dominant · 2019
Where it sits
- A kind of
Other names
3 names
Resolves to: herpes simplex encephalitis, susceptibility to, 4
- Also called
- herpes simplex encephalitis caused by mutation in TICAM1Herpes simplex encephalitis, susceptibility to, type 4TICAM1 herpes simplex encephalitis