herpes simplex encephalitis
Findings
No curated finding names herpes simplex encephalitis yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Herpes simplex virus encephalitis (HSE) is caused by the infection of the central nervous system by Herpes simplex virus (HSV) that could have a devastating clinical course and a potentially fatal outcome particularly with delay or lack of treatment. HSV often involves the frontal and temporal lobes, usually asymmetrically, resulting in personality changes, cognitive impairment, aphasia, seizures, and focal weakness.
Definition from the Mondo Disease Ontology (MONDO:0012521), read 2026-09-29. CC BY 4.0.
Features
30 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Abnormal brain morphologyHPOHP:0012443
- Very frequent (80% to 99% of cases)
- CSF lymphocytic pleiocytosisHPOHP:0200149
- Very frequent (80% to 99% of cases)
- EEG abnormalityHPOHP:0002353
- Very frequent (80% to 99% of cases)
- Reduced consciousnessHPOHP:0004372
- Very frequent (80% to 99% of cases)
- Abnormal speech patternHPOHP:0002167
- Frequent (30% to 79% of cases)
- FatigueHPOHP:0012378
- Frequent (30% to 79% of cases)
- Fever
Show the remaining 18
- Loss of consciousnessHPOHP:0007185
- Frequent (30% to 79% of cases)
- Nausea and vomitingHPOHP:0002017
- Frequent (30% to 79% of cases)
- Nuchal rigidityHPOHP:0031179
- Frequent (30% to 79% of cases)
- Respiratory failure requiring assisted ventilationHPOHP:0004887
- Frequent (30% to 79% of cases)
- SeizureHPOHP:0001250
- Frequent (30% to 79% of cases)
- Addictive alcohol useHPOHP:0030955
- Occasional (5% to 29% of cases)
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- GTF3AHGNC:4662
- Limited · PanelApp Australia · Autosomal recessive · 2025
Where it sits
Other names
9 names
Resolves to: herpes simplex encephalitis
- Also called
- Encephalitis, Herpes SimplexHerpes simplex meningo-encephalitisHerpes simplex neuroinvasionherpetic encephalitisHSEHSV encephalitisHSVESimplexvirus caused infectious encephalitisSimplexvirus infectious encephalitis