hereditary spastic paraplegia 41
Findings
No curated finding names hereditary spastic paraplegia 41 yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Autosomal dominant spastic paraplegia type 41 is a pure form of hereditary spastic paraplegia characterized by onset in adolescence or early adulthood of slowly progressive spastic paraplegia, proximal muscle weakness of the lower extremities and small hand muscles, hyperreflexia, spastic gait and mild urinary compromise.
Definition from the Mondo Disease Ontology (MONDO:0013239), read 2026-09-29. CC BY 4.0.
Features
10 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Degeneration of the lateral corticospinal tractsHPOHP:0002314
- Very frequent (80% to 99% of cases)
- HyperreflexiaHPOHP:0001347
- Very frequent (80% to 99% of cases)
- Lower limb spasticityHPOHP:0002061
- Very frequent (80% to 99% of cases)
- Progressive spastic paraplegiaHPOHP:0007020
- Very frequent (80% to 99% of cases)
- Spastic gaitHPOHP:0002064
- Very frequent (80% to 99% of cases)
- Hand muscle weaknessHPOHP:0030237
- Frequent (30% to 79% of cases)
- Lower limb amyotrophyHPOHP:0007210
- Frequent (30% to 79% of cases)
- Proximal muscle weaknessHPOHP:0003701
- Frequent (30% to 79% of cases)
- Spinal cord lesionHPOHP:0100561
- Frequent (30% to 79% of cases)
- Urinary urgencyHPOHP:0000012
- Frequent (30% to 79% of cases)
Reported absent (4)
- Abnormal cerebrospinal fluid morphologyHPOHP:0002921
- Abnormal lower-limb motor evoked potentialsHPOHP:0012898
- EMG abnormalityHPOHP:0003457
- SeizureHPOHP:0001250
Where it sits
- A kind of
Other names
3 names
Resolves to: hereditary spastic paraplegia 41
- Also called
- autosomal dominant spastic paraplegia type 41hereditary spastic paraplegia type 41SPG41