hereditary spastic paraplegia 37
Findings
No curated finding names hereditary spastic paraplegia 37 yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Autosomal dominant spastic paraplegia type 37 is a pure form of hereditary spastic paraplegia characterized by a childhood- to adulthood-onset of slowly progressive spastic gait, extensor plantar responses, brisk tendon reflexes in arms and legs, decreased vibration sense at ankles and urinary dysfunction. Ankle clonus is also reported in some patients.
Definition from the Mondo Disease Ontology (MONDO:0012766), read 2026-09-29. CC BY 4.0.
Features
16 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Degeneration of the lateral corticospinal tractsHPOHP:0002314
- Very frequent (80% to 99% of cases)
- Progressive spastic paraplegiaHPOHP:0007020
- Very frequent (80% to 99% of cases)
- Babinski signHPOHP:0003487
- Frequent (30% to 79% of cases)
- HyperreflexiaHPOHP:0001347
- Frequent (30% to 79% of cases)
- Impaired vibration sensation in the lower limbsHPOHP:0002166
- Frequent (30% to 79% of cases)
- Lower limb muscle weaknessHPOHP:0007340
- Frequent (30% to 79% of cases)
- Lower limb spasticity
Reported absent (4)
- Abnormal cerebrospinal fluid morphologyHPOHP:0002921
- Abnormal lower-limb motor evoked potentialsHPOHP:0012898
- EMG abnormalityHPOHP:0003457
- SeizureHPOHP:0001250
Show the remaining 4
- Pes cavusHPOHP:0001761
- Occasional (5% to 29% of cases)
- Spastic gaitHPOHP:0002064
- Occasional (5% to 29% of cases)
- Upper limb hyperreflexiaHPOHP:0007350
- Occasional (5% to 29% of cases)
- Urinary urgencyHPOHP:0000012
- Occasional (5% to 29% of cases)
Where it sits
- A kind of
Other names
3 names
Resolves to: hereditary spastic paraplegia 37
- Also called
- autosomal dominant spastic paraplegia type 37hereditary spastic paraplegia type 37SPG37