hereditary spastic paraplegia 36
Findings
No curated finding names hereditary spastic paraplegia 36 yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Autosomal dominant spastic paraplegia type 36 (SPG36) is a complex form of hereditary spastic paraplegia, characterized by an onset in childhood or adulthood of progressive spastic paraplegia (with spastic gait, spasticity, lower limb weakness, pes cavus and urinary urgency) associated with the additional manifestation of peripheral sensorimotor neuropathy.
Definition from the Mondo Disease Ontology (MONDO:0013132), read 2026-09-29. CC BY 4.0.
Features
18 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Babinski signHPOHP:0003487
- Very frequent (80% to 99% of cases)
- HyperreflexiaHPOHP:0001347
- Very frequent (80% to 99% of cases)
- Lower limb spasticityHPOHP:0002061
- Very frequent (80% to 99% of cases)
- Progressive spastic paraplegiaHPOHP:0007020
- Very frequent (80% to 99% of cases)
- Spastic gaitHPOHP:0002064
- Very frequent (80% to 99% of cases)
- Demyelinating motor neuropathyHPOHP:0007220
- Frequent (30% to 79% of cases)
Show the remaining 6
- Proximal muscle weaknessHPOHP:0003701
- Frequent (30% to 79% of cases)
- Urinary incontinenceHPOHP:0000020
- Frequent (30% to 79% of cases)
- Urinary urgencyHPOHP:0000012
- Frequent (30% to 79% of cases)
- ArthritisHPOHP:0001369
- Occasional (5% to 29% of cases)
- Pes cavusHPOHP:0001761
- Occasional (5% to 29% of cases)
- StrabismusHPOHP:0000486
- Occasional (5% to 29% of cases)
Where it sits
Other names
3 names
Resolves to: hereditary spastic paraplegia 36
- Also called
- autosomal dominant spastic paraplegia type 36hereditary spastic paraplegia type 36SPG36