hereditary spastic paraplegia 34
Findings
No curated finding names hereditary spastic paraplegia 34 yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
X-linked spastic paraplegia type 34 is a pure form of hereditary spastic paraplegia characterized by late childhood- to early adulthood-onset of slowly progressive spastic paraplegia with spastic gait and lower limb hyperreflexia, brisk tendon reflexes and ankle clonus. Lower limb pain and reduced lower limb vibratory sense is also reported in some older adult patients.
Definition from the Mondo Disease Ontology (MONDO:0010418), read 2026-09-29. CC BY 4.0.
Features
8 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Ankle clonusHPOHP:0011448
- Frequent (30% to 79% of cases)
- Babinski signHPOHP:0003487
- Frequent (30% to 79% of cases)
- Brisk reflexesHPOHP:0001348
- Frequent (30% to 79% of cases)
- HyperreflexiaHPOHP:0001347
- Frequent (30% to 79% of cases)
- Impaired vibration sensation in the lower limbsHPOHP:0002166
- Frequent (30% to 79% of cases)
- Lower limb painHPOHP:0012514
- Frequent (30% to 79% of cases)
- Lower limb spasticity
Where it sits
- A kind of
Other names
4 names
Resolves to: hereditary spastic paraplegia 34
- Also called
- hereditary spastic paraplegia type 34spastic paraplegia 34, X-linked, X-linked recessiveSPG34X-linked spastic paraplegia type 34