hereditary spastic paraplegia 32
Findings
No curated finding names hereditary spastic paraplegia 32 yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Autosomal recessive spastic paraplegia type 32 (SPG32) is a rare, complex type of hereditary spastic paraplegia characterized by a slowly progressive spastic paraplegia (with walking difficulties appearing at onset at 6-7 years of age) associated with mild intellectual disability. Brain imaging reveals thin corpus callosum, cortical and cerebellar atrophy, and pontine dysraphia. The SPG32 phenotype has been mapped to a locus on chromosome 14q12-q21.
Definition from the Mondo Disease Ontology (MONDO:0012643), read 2026-09-29. CC BY 4.0.
Features
13 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Gait disturbanceHPOHP:0001288
- Obligate (100% of cases)
- Mild intellectual disabilityHPOHP:0001256
- Obligate (100% of cases)
- Pes cavusHPOHP:0001761
- Obligate (100% of cases)
- Abnormal pons morphologyHPOHP:0007361
- Frequent (30% to 79% of cases)
- Babinski signHPOHP:0003487
- Frequent (30% to 79% of cases)
- Cerebellar cortical atrophyHPOHP:0008278
- Frequent (30% to 79% of cases)
- Hypoplasia of the corpus callosumHPO
Show the remaining 1
- Specific learning disabilityHPOHP:0001328
- Frequent (30% to 79% of cases)
Where it sits
Other names
3 names
Resolves to: hereditary spastic paraplegia 32
- Also called
- autosomal recessive spastic paraplegia type 32hereditary spastic paraplegia type 32SPG32