hereditary spastic paraplegia 29
Findings
No curated finding names hereditary spastic paraplegia 29 yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Autosomal dominant spastic paraplegia type 29 (SPG29) is a complex form of hereditary spastic paraplegia characterized by a spastic paraplegia presenting in adolescence, associated with the additional manifestations of sensorial hearing impairment due to auditory neuropathy and persistent vomiting due to a hiatal or paraesophageal hernia.
Definition from the Mondo Disease Ontology (MONDO:0012334), read 2026-09-29. CC BY 4.0.
Features
14 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Babinski signHPOHP:0003487
- Very frequent (80% to 99% of cases)
- Lower limb hyperreflexiaHPOHP:0002395
- Very frequent (80% to 99% of cases)
- Hearing impairmentHPOHP:0000365
- Frequent (30% to 79% of cases)
- HerniaHPOHP:0100790
- Frequent (30% to 79% of cases)
- Hiatus herniaHPOHP:0002036
- Frequent (30% to 79% of cases)
- HyperbilirubinemiaHPOHP:0002904
- Frequent (30% to 79% of cases)
- Pes cavusHPO
Show the remaining 2
- Impaired proprioceptionHPOHP:0010831
- Very rare (1% to 4% of cases)
- SeizureHPOHP:0001250
- Very rare (1% to 4% of cases)
Where it sits
Other names
2 names
Resolves to: hereditary spastic paraplegia 29
- Also called
- hereditary spastic paraplegia type 29SPG29