hereditary spastic paraplegia 27
MONDO:0012181Mondo
Findings
No curated finding names hereditary spastic paraplegia 27 yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A hereditary spastic paraplegia that has material basis in variation in the chromosome region 10q22.1-q24.1.
Definition from the Mondo Disease Ontology (MONDO:0012181), read 2026-09-29. CC BY 4.0.
Features
9 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Babinski signHPOHP:0003487
- Very frequent (80% to 99% of cases)
- Impaired vibration sensation at anklesHPOHP:0006938
- Very frequent (80% to 99% of cases)
- Lower limb hyperreflexiaHPOHP:0002395
- Very frequent (80% to 99% of cases)
- Spastic paraplegiaHPOHP:0001258
- Very frequent (80% to 99% of cases)
- Spastic/hyperactive bladderHPOHP:0005340
- Very frequent (80% to 99% of cases)
- Abnormality of somatosensory evoked potentialsHPOHP:0007377
- Occasional (5% to 29% of cases)
- DysarthriaHPOHP:0001260
- Occasional (5% to 29% of cases)
- DysdiadochokinesisHPOHP:0002075
- Occasional (5% to 29% of cases)
- Sensorineural hearing impairmentHPOHP:0000407
- Very rare (1% to 4% of cases)
Where it sits
Other names
3 names
Resolves to: hereditary spastic paraplegia 27
- Also called
- autosomal recessive spastic paraplegia type 27hereditary spastic paraplegia type 27SPG27