hereditary spastic paraplegia 25
Findings
No curated finding names hereditary spastic paraplegia 25 yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Autosomal recessive spastic paraplegia type 25 (SPG25) is a rare, complex type of hereditary spastic paraplegia characterized by adult-onset spastic paraplegia associated with spinal pain that radiates to the upper or lower limbs and is related to disk herniation (with minor spondylosis), as well as mild sensorimotor neuropathy. The SPG25 phenotype has been mapped to a locus on chromosome 6q23-q24.1.
Definition from the Mondo Disease Ontology (MONDO:0011992), read 2026-09-29. CC BY 4.0.
Features
13 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Herniation of intervertebral nucleiHPOHP:0008441
- Very frequent (80% to 99% of cases)
- ParaparesisHPOHP:0002385
- Very frequent (80% to 99% of cases)
- Lower limb painHPOHP:0012514
- Frequent (30% to 79% of cases)
- Neck painHPOHP:0030833
- Frequent (30% to 79% of cases)
- Sensory neuropathyHPOHP:0000763
- Frequent (30% to 79% of cases)
- Spastic paraplegiaHPOHP:0001258
- Frequent (30% to 79% of cases)
- Abnormal lumbar spine morphology
Show the remaining 1
- Upper limb painHPOHP:0012513
- Occasional (5% to 29% of cases)
Where it sits
Other names
4 names
Resolves to: hereditary spastic paraplegia 25
- Also called
- autosomal recessive spastic paraplegia type 25autosomal recessive spastic paraplegia-disc herniation syndromehereditary spastic paraplegia type 25SPG25