hereditary spastic paraplegia 19
Findings
No curated finding names hereditary spastic paraplegia 19 yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Autosomal dominant spastic paraplegia type 19 is a pure form of hereditary spastic paraplegia characterized by a slowly progressive and relatively benign spastic paraplegia presenting in adulthood with spastic gait, lower limb hyperreflexia, extensor plantar responses, bladder dysfunction (urinary urgency and/or incontinence), and mild sensory and motor peripheral neuropathy.
Definition from the Mondo Disease Ontology (MONDO:0011785), read 2026-09-29. CC BY 4.0.
Features
21 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Babinski signHPOHP:0003487
- Very frequent (80% to 99% of cases)
- Degeneration of the lateral corticospinal tractsHPOHP:0002314
- Very frequent (80% to 99% of cases)
- HyperreflexiaHPOHP:0001347
- Very frequent (80% to 99% of cases)
- Lower limb muscle weaknessHPOHP:0007340
- Very frequent (80% to 99% of cases)
- Lower limb spasticityHPOHP:0002061
- Very frequent (80% to 99% of cases)
- Progressive spastic paraplegiaHPOHP:0007020
- Very frequent (80% to 99% of cases)
Show the remaining 9
- Limb ataxiaHPOHP:0002070
- Frequent (30% to 79% of cases)
- Lower limb amyotrophyHPOHP:0007210
- Frequent (30% to 79% of cases)
- Male sexual dysfunctionHPOHP:0040307
- Frequent (30% to 79% of cases)
- Muscle spasmHPOHP:0003394
- Frequent (30% to 79% of cases)
- Spinal cord lesionHPOHP:0100561
- Frequent (30% to 79% of cases)
- Gait disturbanceHPOHP:0001288
- Occasional (5% to 29% of cases)
Where it sits
- A kind of
Other names
3 names
Resolves to: hereditary spastic paraplegia 19
- Also called
- autosomal dominant spastic paraplegia type 19hereditary spastic paraplegia type 19SPG19