harlequin syndrome
Findings
No curated finding names harlequin syndrome yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Harlequin syndrome (HSD) is an autonomic disorder occurring at any age and characterized by unilateral flushing and sweating, involving the face and sometimes arm and chest, in condition of thermal, exercise or emotional stress without sympathetic ocular manifestations. However, tonic pupils, parasympathetic oculomotor lesion and pre- or postganglionic sudomotor sympathetic deficit can rarely occur.
Definition from the Mondo Disease Ontology (MONDO:0016040), read 2026-09-29. CC BY 4.0.
Features
10 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- AnhidrosisHPOHP:0000970
- Frequent (30% to 79% of cases)
- ColdnessHPOHP:0033850
- Frequent (30% to 79% of cases)
- FlushingHPOHP:0031284
- Frequent (30% to 79% of cases)
- Horner syndromeHPOHP:0002277
- Frequent (30% to 79% of cases)
- PallorHPOHP:0000980
- Frequent (30% to 79% of cases)
- Cluster headacheHPOHP:0012199
- Occasional (5% to 29% of cases)
- EpiphoraHPOHP:0009926
Where it sits
- A kind of
Other names
1 name
Resolves to: harlequin syndrome
- Also called
- progressive isolated segmental anhidrosis