Gorham-Stout disease
Findings
No curated finding names Gorham-Stout disease yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Gorham-Stout disease (GSD) is a rare disease of massive osteolysis associated with proliferation and dilation of lymphatic vessels. GSD may affect any bone in the body and can be monostotic or polyostotic. Symptoms at presentation are dependent upon the location(s) of the disease; the most common symptom is localized pain. The disease may be discovered after a pathological fracture.
Definition from the Mondo Disease Ontology (MONDO:0007414), read 2026-09-29. CC BY 4.0.
Features
36 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Elevated alkaline phosphatase of bone originHPOHP:0010639
- Very frequent (80% to 99% of cases)
- OsteolysisHPOHP:0002797
- Very frequent (80% to 99% of cases)
- Patchy reduction of bone mineral densityHPOHP:0010657
- Very frequent (80% to 99% of cases)
- Abnormal bone ossificationHPOHP:0011849
- Frequent (30% to 79% of cases)
- Abnormal calvaria morphologyHPOHP:0002683
- Frequent (30% to 79% of cases)
- Abnormal facial skeleton morphologyHPOHP:0011821
- Frequent (30% to 79% of cases)
Show the remaining 24
- EdemaHPOHP:0000969
- Frequent (30% to 79% of cases)
- Functional motor deficitHPOHP:0004302
- Frequent (30% to 79% of cases)
- Impaired masticationHPOHP:0005216
- Frequent (30% to 79% of cases)
- LymphangiomaHPOHP:0100764
- Frequent (30% to 79% of cases)
- Mandibular painHPOHP:0200025
- Frequent (30% to 79% of cases)
- Osteolysis involving bones of the lower limbsHPOHP:0009139
- Frequent (30% to 79% of cases)
Where it sits
Other names
5 names
Resolves to: Gorham-Stout disease
- Also called
- Gorham diseaseGorham syndromeidiopathic massive osteolysisprogressive massive osteolysisvanishing bone disease