glomerulopathy with fibronectin deposits 2
Findings
No curated finding names glomerulopathy with fibronectin deposits 2 yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Any fibronectin glomerulopathy in which the cause of the disease is a mutation in the FN1 gene.
Definition from the Mondo Disease Ontology (MONDO:0011165), read 2026-09-29. CC BY 4.0.
- Inheritance
- Autosomal dominant inheritance
- Onset and course
- Juvenile onset · Slowly progressive · Young adult onset
HPO, annotations 2026-09-02
Features
9 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Glomerular depositsHPOHP:0030949
- 5 of 5 reported patients
- Glomerular fibronectin depositsHPOHP:6000428
- 5 of 5 reported patients
- GlomerulomegalyHPOHP:0030162
- 5 of 5 reported patients
- ProteinuriaHPOHP:0000093
- 8 of 8 reported patients
- HypertensionHPOHP:0000822
- 7 of 8 reported patients
- Nephrotic syndromeHPOHP:0000100
- 6 of 8 reported patients
- Microscopic hematuriaHPOHP:0002907
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- FN1HGNC:3778
- Strong · Labcorp Genetics (formerly Invitae) · Autosomal dominant · 2022
- Strong · PanelApp Australia · Autosomal dominant · 2025
- Moderate · Ambry Genetics · Autosomal dominant · 2023
- Moderate · ClinGen · Autosomal dominant · 2023
Where it sits
- A kind of
Other names
3 names
Resolves to: glomerulopathy with fibronectin deposits 2
- Also called
- fibronectin glomerulopathy caused by mutation in FN1FN1 fibronectin glomerulopathyglomerulopathy with fibronectin deposits type 2