glioblastoma
Findings
No curated finding names glioblastoma yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
The most malignant astrocytic tumor (WHO grade IV). It is composed of poorly differentiated neoplastic astrocytes and it is characterized by the presence of cellular polymorphism, nuclear atypia, brisk mitotic activity, vascular thrombosis, microvascular proliferation and necrosis. It typically affects adults and is preferentially located in the cerebral hemispheres. It may develop from diffuse astrocytoma WHO grade II or anaplastic astrocytoma (secondary glioblastoma, IDH-mutant), but more frequently, it manifests after a short clinical history de novo, without evidence of a less malignant precursor lesion (primary glioblastoma, IDH- wildtype). (Adapted from WHO)
Definition from the Mondo Disease Ontology (MONDO:0018177), read 2026-09-29. CC BY 4.0.
Features
15 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Glioblastoma multiformeHPOHP:0012174
- Obligate (100% of cases)
- Abnormal cell morphologyHPOHP:0025461
- Very frequent (80% to 99% of cases)
- Abnormal cerebral white matter morphologyHPOHP:0002500
- Frequent (30% to 79% of cases)
- Abnormal corpus callosum morphologyHPOHP:0001273
- Frequent (30% to 79% of cases)
- Abnormal nervous system physiologyHPOHP:0012638
- Frequent (30% to 79% of cases)
- Cerebral edemaHPOHP:0002181
- Frequent (30% to 79% of cases)
Show the remaining 3
- Visual lossHPOHP:0000572
- Frequent (30% to 79% of cases)
- Memory impairmentHPOHP:0002354
- Occasional (5% to 29% of cases)
- SeizureHPOHP:0001250
- Occasional (5% to 29% of cases)
Where it sits
- A kind of
Other names
11 names
Resolves to: glioblastoma
- Also called
- GBMGBM (glioblastoma)glioblastoma (disease)glioblastoma multiformeglioblastoma multiforme (disease)grade IV astrocytic neoplasmgrade IV astrocytic tumorgrade IV astrocytic tumourgrade IV astrocytomaspongioblastoma multiformeWHO grade IV glioma