glaucoma secondary to spherophakia/ectopia lentis and megalocornea
Findings
No curated finding names glaucoma secondary to spherophakia/ectopia lentis and megalocornea yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Glaucoma secondary to spherophakia/ectopia lentis and megalocornea is a rare, genetic, non-syndromic developmental defect of the eye disorder characterized by congenital megalocornea associated with spherophakia and/or ectopia lentis leading to pupillary block and secondary glaucoma. Additional features may include flat irides, iridodonesis, axial myopia, very deep anterior chambers, miotic, oval pupils without well-defined borders, ocular pain and irritability manifesting as conjunctival injection, corneal edema and central scarring, as well as a high arched palate.
Definition from the Mondo Disease Ontology (MONDO:0016559), read 2026-09-29. CC BY 4.0.
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- LTBP2HGNC:6715
- Supportive · Orphanet · Autosomal recessive · 2021
Where it sits
Other names
1 name
Resolves to: glaucoma secondary to spherophakia/ectopia lentis and megalocornea
- Also called
- megalocornea-spherophakia-secondary glaucoma syndrome