gamma-heavy chain disease
MONDO:0015046Mondo
Findings
No curated finding names gamma-heavy chain disease yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Gamma-heavy chain disease (gamma-HCD) is a type of HCD characterized by the production of incomplete monoclonal gamma-heavy chains without associated light chains. The clinical presentation most commonly resembles that of patients with systemic lymphoproliferative/autoimmune diseases.
Definition from the Mondo Disease Ontology (MONDO:0015046), read 2026-09-29. CC BY 4.0.
Features
20 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Abnormal bone marrow cell morphologyHPOHP:0005561
- Very frequent (80% to 99% of cases)
- Abnormal lymphocyte morphologyHPOHP:0004332
- Very frequent (80% to 99% of cases)
- FatigueHPOHP:0012378
- Very frequent (80% to 99% of cases)
- FeverHPOHP:0001945
- Very frequent (80% to 99% of cases)
- AnemiaHPOHP:0001903
- Frequent (30% to 79% of cases)
- HepatomegalyHPOHP:0002240
- Frequent (30% to 79% of cases)
- LymphadenopathyHPOHP:0002716
- Frequent (30% to 79% of cases)
- Neoplasm of the tongueHPOHP:0100648
- Frequent (30% to 79% of cases)
- Skin rashHPOHP:0000988
- Frequent (30% to 79% of cases)
- SplenomegalyHPOHP:0001744
- Frequent (30% to 79% of cases)
- Abnormal palate morphologyHPOHP:0000174
- Occasional (5% to 29% of cases)
- Autoimmune hemolytic anemiaHPOHP:0001890
- Occasional (5% to 29% of cases)
Show the remaining 8
- Autoimmune thrombocytopeniaHPOHP:0001973
- Occasional (5% to 29% of cases)
- AutoimmunityHPOHP:0002960
- Occasional (5% to 29% of cases)
- DysphagiaHPOHP:0002015
- Occasional (5% to 29% of cases)
- OsteolysisHPOHP:0002797
- Occasional (5% to 29% of cases)
- Peripheral neuropathyHPOHP:0009830
- Occasional (5% to 29% of cases)
- Recurrent respiratory infectionsHPOHP:0002205
- Occasional (5% to 29% of cases)
Where it sits
- A kind of
Other names
4 names
Resolves to: gamma-heavy chain disease
- Also called
- Franklin diseaseFranklin's diseasegamma heavy chain diseasegamma-HCD