functioning gonadotropic adenoma
Findings
No curated finding names functioning gonadotropic adenoma yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Functioning gonadotropic adenoma is a very rare pituitary tumor, macroscopically characterized by a soft, well vascularized, variable sized adenoma, with occasional areas of hemorrage or necrosis, that secretes biologically active gonadotropins. In addition to common neurological signs due to mass effect (headache and/or visual field deterioration), additional clinical manifestations include menstrual irregularities (secondary amenorrhea, oligomenorhea or severe menorrhagia), galactorrhea, infertility or ovarian hyperstimulation syndrome (in premenopausal women), testicular enlargement and, occasionally, hypogonadism (in men) and isosexual precocious puberty (in children).
Definition from the Mondo Disease Ontology (MONDO:0019612), read 2026-09-29. CC BY 4.0.
Features
34 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Pituitary gonadotropic cell adenomaHPOHP:0011759
- Obligate (100% of cases)
- Abnormal prolactin levelHPOHP:0040086
- Frequent (30% to 79% of cases)
- Abnormality of the menstrual cycleHPOHP:0000140
- Frequent (30% to 79% of cases)
- Anterior hypopituitarismHPOHP:0000830
- Frequent (30% to 79% of cases)
- Decreased female libidoHPOHP:0030018
- Frequent (30% to 79% of cases)
- FatigueHPOHP:0012378
- Frequent (30% to 79% of cases)
- Impotence
Show the remaining 22
- Adrenocorticotropic hormone deficiencyHPOHP:0011748
- Occasional (5% to 29% of cases)
- AmenorrheaHPOHP:0000141
- Occasional (5% to 29% of cases)
- AscitesHPOHP:0001541
- Occasional (5% to 29% of cases)
- Central diabetes insipidusHPOHP:0000863
- Occasional (5% to 29% of cases)
- Decreased response to growth hormone stimulation testHPOHP:0000824
- Occasional (5% to 29% of cases)
- Deep venous thrombosisHPOHP:0002625
- Occasional (5% to 29% of cases)
Where it sits
- A kind of
Other names
2 names
Resolves to: functioning gonadotropic adenoma
- Also called
- functioning pituitary gonadotropic adenomagonadotroph adenoma