frontotemporal dementia and/or amyotrophic lateral sclerosis 8
MONDO:0030872Mondo
Findings
No curated finding names frontotemporal dementia and/or amyotrophic lateral sclerosis 8 yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
- Inheritance
- Autosomal dominant inheritance
- Onset and course
- Late onset · Middle age onset · Young adult onset
HPO, annotations 2026-09-02
Features
11 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- DementiaHPOHP:0000726
- 12 of 12 reported patients
- DyscalculiaHPOHP:0002442
- 2 of 2 reported patients
- Memory impairmentHPOHP:0002354
- 12 of 12 reported patients
- EcholaliaHPOHP:0010529
- 1 of 2 reported patients
- Global brain atrophyHPOHP:0002283
- 1 of 2 reported patients
- Impaired executive functioningHPOHP:0033051
- 1 of 2 reported patients
- Amyotrophic lateral sclerosisHPOHP:0007354
- AphasiaHPOHP:0002381
- Atypical behaviorHPOHP:0000708
- Frontotemporal dementiaHPOHP:0002145
- Neurofibrillary tanglesHPOHP:0002185
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- CYLDHGNC:2584
- Strong · Labcorp Genetics (formerly Invitae) · Autosomal dominant · 2022
- Limited · ClinGen · Autosomal dominant · 2023
Where it sits
Other names
1 name
Resolves to: frontotemporal dementia and/or amyotrophic lateral sclerosis 8
- Also called
- FTDALS8