Freiberg disease
Findings
No curated finding names Freiberg disease yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Freiberg's disease is rare condition that primarily affects the second or third metatarsal (the long bones of the foot). Although people of all ages can be affected by this condition, Freiberg's disease is most commonly diagnosed during adolescence through the second decade of life. Common signs and symptoms include pain and stiffness in the front of the foot, which often leads to a limp. Affected people may also experience swelling, limited range of motion, and tenderness of the affected foot. Symptoms are generally triggered by weight-bearing activities, including walking. The exact underlying cause of Freiberg's disease is currently unknown. Treatment depends on many factors, including the severity of condition; the signs and symptoms present; and the age of the patient.
Definition from the Mondo Disease Ontology (MONDO:0023188), read 2026-09-29. CC BY 4.0.
Features
19 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Abnormal metatarsal epiphysis morphologyHPOHP:0010630
- Frequent (30% to 79% of cases)
- Abnormality of the second metatarsal boneHPOHP:0040034
- Frequent (30% to 79% of cases)
- ArthralgiaHPOHP:0002829
- Frequent (30% to 79% of cases)
- ArthritisHPOHP:0001369
- Frequent (30% to 79% of cases)
- ChondritisHPOHP:0100662
- Frequent (30% to 79% of cases)
- Flattened metatarsal headsHPOHP:0005194
- Frequent (30% to 79% of cases)
- Foot pain
Show the remaining 7
- Sclerosis of foot boneHPOHP:0100925
- Frequent (30% to 79% of cases)
- Structural foot deformityHPOHP:0010219
- Frequent (30% to 79% of cases)
- Thickened cortex of bonesHPOHP:0100039
- Frequent (30% to 79% of cases)
- Abnormality of the third metatarsal boneHPOHP:0010672
- Occasional (5% to 29% of cases)
- Avascular necrosisHPOHP:0010885
- Occasional (5% to 29% of cases)
- Abnormality of the fifth metatarsal boneHPOHP:0008089
- Very rare (1% to 4% of cases)
Where it sits
- A kind of
Other names
1 name
Resolves to: Freiberg disease
- Also called
- Freiberg's disease