fetal and neonatal alloimmune thrombocytopenia
Findings
No curated finding names fetal and neonatal alloimmune thrombocytopenia yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A rare hematological disease characterized by maternal alloimmunisation against fetal platelet antigens that are inherited from the father and different from those present in the mother, and usually presents as a severe isolated thrombocytopenia in otherwise healthy newborns.
Definition from the Mondo Disease Ontology (MONDO:0019415), read 2026-09-29. CC BY 4.0.
Features
17 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Neonatal alloimmune thrombocytopeniaHPOHP:0004809
- Obligate (100% of cases)
- Abnormal bleedingHPOHP:0001892
- Frequent (30% to 79% of cases)
- CephalohematomaHPOHP:0012541
- Frequent (30% to 79% of cases)
- PetechiaeHPOHP:0000967
- Frequent (30% to 79% of cases)
- PurpuraHPOHP:0000979
- Frequent (30% to 79% of cases)
- Spontaneous hematomasHPOHP:0007420
- Frequent (30% to 79% of cases)
- EcchymosisHPOHP:0031364
- Occasional (5% to 29% of cases)
- Gastrointestinal hemorrhageHPOHP:0002239
- Occasional (5% to 29% of cases)
- HematuriaHPOHP:0000790
- Occasional (5% to 29% of cases)
- Intracranial hemorrhageHPOHP:0002170
- Occasional (5% to 29% of cases)
- MelenaHPOHP:0002249
- Occasional (5% to 29% of cases)
- Abnormality of the nervous systemHPOHP:0000707
- Very rare (1% to 4% of cases)
Show the remaining 5
- Bilateral sensorineural hearing impairmentHPOHP:0008619
- Very rare (1% to 4% of cases)
- BlindnessHPOHP:0000618
- Very rare (1% to 4% of cases)
- Cerebral palsyHPOHP:0100021
- Very rare (1% to 4% of cases)
- Global developmental delayHPOHP:0001263
- Very rare (1% to 4% of cases)
- Subarachnoid hemorrhageHPOHP:0002138
- Very rare (1% to 4% of cases)
Where it sits
Other names
1 name
Resolves to: fetal and neonatal alloimmune thrombocytopenia
- Also called
- NAIT