familial pancreatic carcinoma
Findings
No curated finding names familial pancreatic carcinoma yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Familial pancreatic carcinoma is defined by the presence of pancreatic cancer (PC) in two or more first-degree relatives.
Definition from the Mondo Disease Ontology (MONDO:0015278), read 2026-09-29. CC BY 4.0.
Features
25 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Pancreatic adenocarcinomaHPOHP:0006725
- Obligate (100% of cases)
- Abdominal painHPOHP:0002027
- Very frequent (80% to 99% of cases)
- AnorexiaHPOHP:0002039
- Very frequent (80% to 99% of cases)
- Back painHPOHP:0003418
- Very frequent (80% to 99% of cases)
- Chronic fatigueHPOHP:0012432
- Very frequent (80% to 99% of cases)
- Exocrine pancreatic insufficiencyHPOHP:0001738
- Very frequent (80% to 99% of cases)
- Poor appetiteHPOHP:0004396
- Very frequent (80% to 99% of cases)
- Weight lossHPOHP:0001824
- Very frequent (80% to 99% of cases)
- Extrahepatic cholestasisHPOHP:0012334
- Frequent (30% to 79% of cases)
- Functional intestinal obstructionHPOHP:0005249
- Frequent (30% to 79% of cases)
- Intestinal pseudo-obstructionHPOHP:0004389
- Frequent (30% to 79% of cases)
- JaundiceHPOHP:0000952
- Frequent (30% to 79% of cases)
Show the remaining 13
- LymphadenopathyHPOHP:0002716
- Frequent (30% to 79% of cases)
- Breast carcinomaHPOHP:0003002
- Occasional (5% to 29% of cases)
- Colon cancerHPOHP:0003003
- Occasional (5% to 29% of cases)
- Diabetes mellitusHPOHP:0000819
- Occasional (5% to 29% of cases)
- Elevated circulating hepatic transaminase concentrationHPOHP:0002910
- Occasional (5% to 29% of cases)
- HepatosplenomegalyHPOHP:0001433
- Occasional (5% to 29% of cases)
Genes
3 genes
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
Where it sits
Other names
6 names
Resolves to: familial pancreatic carcinoma
- Also called
- familial pancreatic cancerhereditary exocrine pancreatic carcinomahereditary pancreatic cancerhereditary pancreatic carcinomapancreatic cancer, somaticpancreatic carcinoma, somatic