familial or sporadic hemiplegic migraine
Findings
No curated finding names familial or sporadic hemiplegic migraine yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Hemiplegic migraine (HM) is a rare variety of migraine with aura characterized by the presence of a motor weakness during the aura. Hemiplegic migraine has two main forms depending on the familial history: patients with at least one first- or second-degree relative who has aura including motor weakness have familial hemiplegic migraine (FHM); patients without such familial history have sporadic hemiplegic migraine (SHM).
Definition from the Mondo Disease Ontology (MONDO:0018925), read 2026-09-29. CC BY 4.0.
Features
51 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Abnormal speech patternHPOHP:0002167
- Very frequent (80% to 99% of cases)
- EEG abnormalityHPOHP:0002353
- Very frequent (80% to 99% of cases)
- Focal motor seizureHPOHP:0011153
- Very frequent (80% to 99% of cases)
- Focal sensory seizureHPOHP:0011157
- Very frequent (80% to 99% of cases)
- Migraine with auraHPOHP:0002077
- Very frequent (80% to 99% of cases)
- Muscle weaknessHPOHP:0001324
- Very frequent (80% to 99% of cases)
Show the remaining 39
- Dissociated sensory lossHPOHP:0010835
- Frequent (30% to 79% of cases)
- DysarthriaHPOHP:0001260
- Frequent (30% to 79% of cases)
- Facial ticsHPOHP:0011468
- Frequent (30% to 79% of cases)
- Focal manual automatism seizureHPOHP:0032900
- Frequent (30% to 79% of cases)
- Focal pedal automatism seizureHPOHP:0032901
- Frequent (30% to 79% of cases)
- Hearing impairmentHPOHP:0000365
- Frequent (30% to 79% of cases)
Genes
4 genes
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
Where it sits
- A kind of
- Narrower terms (2)
Other names
1 name
Resolves to: familial or sporadic hemiplegic migraine
- Also called
- Hemiplegic Migraine