familial male-limited precocious puberty
Findings
No curated finding names familial male-limited precocious puberty yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Familial male limited precocious puberty (FMPP) is a gonadotropin-independent familial form of male-limited precocious puberty, generally presenting between 2-5 years of age as accelerated growth, early development of secondary sexual characteristics and reduced adult height.
Definition from the Mondo Disease Ontology (MONDO:0008303), read 2026-09-29. CC BY 4.0.
- Inheritance
- Sex-limited expression
HPO, annotations 2026-09-02
Features
12 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Accelerated skeletal maturationHPOHP:0005616
- Very frequent (80% to 99% of cases)
- Male infertilityHPOHP:0003251
- Very frequent (80% to 99% of cases)
- Precocious pubertyHPOHP:0000826
- Very frequent (80% to 99% of cases)
- Tall statureHPOHP:0000098
- Very frequent (80% to 99% of cases)
- Abnormal hair morphologyHPOHP:0001595
- Frequent (30% to 79% of cases)
- AcneHPOHP:0001061
- Frequent (30% to 79% of cases)
- Long penis
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- LHCGRHGNC:6585
- Strong · Labcorp Genetics (formerly Invitae) · Autosomal dominant · 2021
- Strong · PanelApp Australia · Autosomal dominant · 2025
- Supportive · Orphanet · Autosomal dominant · 2021
Where it sits
Other names
9 names
Resolves to: familial male-limited precocious puberty
- Also called
- familial gonadotropin-independent male-limited sexual precocityFMPPleydig cell adenoma, somatic, with precocious pubertyLHCGR peripheral precocious pubertymale-limited precocious pubertyperipheral precocious puberty caused by mutation in LHCGRprecocious puberty, maletestotoxicosistestotoxicosis, familial