familial hyperaldosteronism type II
Findings
No curated finding names familial hyperaldosteronism type II yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Familial hyperaldosteronism type II (FH-II) is a heritable form of primary aldosteronism (PA) characterized by hypertension of varying severity, and non glucocticoid remediable hyperaldosteronism.
Definition from the Mondo Disease Ontology (MONDO:0011576), read 2026-09-29. CC BY 4.0.
- Inheritance
- Autosomal dominant inheritance · Typified by incomplete penetrance
- Onset and course
- Juvenile onset
HPO, annotations 2026-09-02
Features
14 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- HypertensionHPOHP:0000822
- 1 of 1 reported patient
- Obligate (100% of cases)
- HypokalemiaHPOHP:0002900
- 1 of 1 reported patient
- Occasional (5% to 29% of cases)
- Abnormal circulating renin concentrationHPOHP:0040084
- Very frequent (80% to 99% of cases)
- Glucocortocoid-insensitive primary hyperaldosteronismHPOHP:0011740
- Very frequent (80% to 99% of cases)
- Secretory adrenocortical adenomaHPOHP:0011746
- Frequent (30% to 79% of cases)
- Adrenal hyperplasiaHPOHP:0008221
- Occasional (5% to 29% of cases)
Show the remaining 2
- TinnitusHPOHP:0000360
- Occasional (5% to 29% of cases)
- Increased circulating aldosterone concentrationHPOHP:0000859
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- CLCN2HGNC:2020
- Moderate · Ambry Genetics · Autosomal dominant · 2018
- Supportive · Orphanet · Autosomal dominant · 2021
Where it sits
Other names
4 names
Resolves to: familial hyperaldosteronism type II
- Also called
- familial adrenal adenomafamilial hyperaldosteronism type 2FH-IIFH2