familial avascular necrosis of femoral head
Findings
No curated finding names familial avascular necrosis of femoral head yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Avascular necrosis of femoral head (ANFH) is a severely disabling disease characterized by progressive groin pain, a limping gait, leg length discrepancy, collapse of the subchondral bone, limitation of hip function and eventual degeneration of the hip joint requiring total hip arthroplasty.
Definition from the Mondo Disease Ontology (MONDO:0012126), read 2026-09-29. CC BY 4.0.
Features
9 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Abnormal femoral neck/head morphologyHPOHP:0003366
- Very frequent (80% to 99% of cases)
- Groin painHPOHP:0031520
- Very frequent (80% to 99% of cases)
- Flattened femoral headHPOHP:0008812
- Frequent (30% to 79% of cases)
- Hip osteoarthritisHPOHP:0008843
- Frequent (30% to 79% of cases)
- Hip painHPOHP:0030838
- Frequent (30% to 79% of cases)
- Impairment of activities of daily livingHPOHP:0031058
- Frequent (30% to 79% of cases)
- Limited hip movementHPOHP:0008800
- Frequent (30% to 79% of cases)
- Lower limb asymmetryHPOHP:0100559
- Frequent (30% to 79% of cases)
- Short stepped shuffling gaitHPOHP:0007311
- Frequent (30% to 79% of cases)
Genes
2 genes
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
Where it sits
Other names
3 names
Resolves to: familial avascular necrosis of femoral head
- Also called
- aseptic Necrosis of femoral headaseptic Necrosis of head of femurfamilial osteonecrosis of the femoral head