esophageal adenocarcinoma
Findings
No curated finding names esophageal adenocarcinoma yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A malignant tumor with glandular differentiation arising predominantly from Barrett mucosa in the lower third of the esophagus. Rare examples of esophageal adenocarcinoma deriving from ectopic gastric mucosa in the upper esophagus have also been reported. Grossly, esophageal adenocarcinomas are similar to esophageal squamous cell carcinomas. Microscopically, adenocarcinomas arising in the setting of Barrett esophagus are typically papillary and/or tubular. The prognosis is poor.
Definition from the Mondo Disease Ontology (MONDO:0005028), read 2026-09-29. CC BY 4.0.
Features
10 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Barrett esophagusHPOHP:0100580
- Very frequent (80% to 99% of cases)
- Clinodactyly of the 5th toeHPOHP:0001864
- Very frequent (80% to 99% of cases)
- Esophageal carcinomaHPOHP:0011459
- Very frequent (80% to 99% of cases)
- Feeding difficulties in infancyHPOHP:0008872
- Very frequent (80% to 99% of cases)
- Gastroesophageal refluxHPOHP:0002020
- Very frequent (80% to 99% of cases)
- ObesityHPOHP:0001513
- Very frequent (80% to 99% of cases)
Where it sits
- A kind of
Other names
9 names
Resolves to: esophageal adenocarcinoma
- Also called
- adenocarcinoma - esophagusadenocarcinoma - oesophagusadenocarcinoma of esophagusadenocarcinoma of oesophagusadenocarcinoma of the esophagusadenocarcinoma of the oesophagusesophagus adenocarcinomaoesophageal adenocarcinomaoesophagus adenocarcinoma