epilepsy, familial temporal lobe, 1
Findings
No curated finding names epilepsy, familial temporal lobe, 1 yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
An autosomal dominant condition caused by mutation(s) in the LGI1 gene, encoding leucine-rich glioma-inactivated protein 1. It is characterized by partial seizures originating in the temporal lobe and often accompanied by auditory sensory manifestations.
Definition from the Mondo Disease Ontology (MONDO:0700090), read 2026-09-29. CC BY 4.0.
- Inheritance
- Autosomal dominant inheritance
- Onset and course
- Middle age onset · Juvenile onset · Young adult onset
HPO, annotations 2026-09-02
Features
15 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Bilateral tonic-clonic seizureHPOHP:0002069
- 12 of 12 reported patients
- Bilateral tonic-clonic seizure with focal onsetHPOHP:0007334
- 12 of 18 reported patients
- Focal aware seizureHPOHP:0002349
- 15 of 30 reported patients
- Focal sensory seizure with auditory featuresHPOHP:0011158
- 13 of 29 reported patients
- Focal autonomic seizure with epigastric sensation/nausea/vomiting/other gastrointestinal phenomenaHPOHP:0011159
- 4 of 11 reported patients
- Focal aware sensory seizure with auditory featuresHPOHP:0032864
- 4 of 12 reported patients
Show the remaining 3
- Focal clonic seizureHPOHP:0002266
- 1 of 11 reported patients
- Focal sensory seizure with olfactory featuresHPOHP:0011161
- 1 of 11 reported patients
- Focal sensory seizure with vestibular featuresHPOHP:0032759
- 1 of 11 reported patients
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- LGI1HGNC:6572
- Strong · Labcorp Genetics (formerly Invitae) · Autosomal dominant · 2020
Where it sits
- A kind of
Other names
6 names
Resolves to: epilepsy, familial temporal lobe, 1
- Also called
- ADLTEADPEAFepilepsy, familial temporal lobe, type 1epilepsy, lateral temporal lobe, autosomal dominantepilepsy, partial, with auditory featuresETL1