eosinophilic granulomatosis with polyangiitis
MONDO:0015943Mondo
Findings
No curated finding names eosinophilic granulomatosis with polyangiitis yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Eosinophilic granulomatosis with polyangiitis (EGPA), previously known as Churg-Strauss syndrome, is a systemic vasculitis of small-to medium vessels, characterized by asthma, transient pulmonary infiltrates, and hypereosinophilia.
Definition from the Mondo Disease Ontology (MONDO:0015943), read 2026-09-29. CC BY 4.0.
Features
67 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- AsthmaHPO · MondoHP:0002099
- Very frequent (80% to 99% of cases)
- AutoimmunityHPOHP:0002960
- Very frequent (80% to 99% of cases)
- Central nervous system degenerationHPOHP:0007009
- Very frequent (80% to 99% of cases)
- Increased inflammatory responseHPOHP:0012649
- Very frequent (80% to 99% of cases)
- Increased total eosinophil countHPOHP:0001880
- Very frequent (80% to 99% of cases)
- Peripheral neuropathyHPOHP:0009830
- Very frequent (80% to 99% of cases)
- Pulmonary infiltratesHPOHP:0002113
- Very frequent (80% to 99% of cases)
- PurpuraHPOHP:0000979
- Very frequent (80% to 99% of cases)
- SinusitisHPOHP:0000246
- Very frequent (80% to 99% of cases)
- UrticariaHPOHP:0001025
- Very frequent (80% to 99% of cases)
- VasculitisHPOHP:0002633
- Very frequent (80% to 99% of cases)
- Weight lossHPOHP:0001824
- Very frequent (80% to 99% of cases)
Show the remaining 55
- Abdominal painHPOHP:0002027
- Frequent (30% to 79% of cases)
- Abnormal pericardium morphologyHPOHP:0001697
- Frequent (30% to 79% of cases)
- Abnormal pleura morphologyHPOHP:0002103
- Frequent (30% to 79% of cases)
- Airway obstructionHPOHP:0006536
- Frequent (30% to 79% of cases)
- Anti-myeloperoxidase antibody positivityHPOHP:0033559
- Frequent (30% to 79% of cases)
- Anti-neutrophil elastase antibody positivityHPOHP:0034104
- Frequent (30% to 79% of cases)
Where it sits
Other names
36 names
Resolves to: eosinophilic granulomatosis with polyangiitis
- Also called
- allergic angiitidesallergic angiitides, granulomatousallergic angiitisallergic angiitis and granulomatosisallergic angiitis, granulomatousallergic granulomatosesallergic granulomatosisallergic granulomatous and angiitisallergic granulomatous Angiitidesallergic granulomatous angiitisangiitides, allergicangiitides, allergic granulomatousangiitides, granulomatous allergicangiitis, allergicangiitis, allergic granulomatous