early-onset autosomal dominant Alzheimer disease
Findings
No curated finding names early-onset autosomal dominant Alzheimer disease yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A progressive dementia with reduction of cognitive functions. It presents the same phenotype as sporadic Alzheimer disease (AD) but has an early age of onset, usually before 60 years old.
Definition from the Mondo Disease Ontology (MONDO:0015140), read 2026-09-29. CC BY 4.0.
Features
26 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Abnormal social behaviorHPOHP:0012433
- Very frequent (80% to 99% of cases)
- AgitationHPOHP:0000713
- Very frequent (80% to 99% of cases)
- Cerebral cortical atrophyHPOHP:0002120
- Very frequent (80% to 99% of cases)
- ConfusionHPOHP:0001289
- Very frequent (80% to 99% of cases)
- DementiaHPOHP:0000726
- Very frequent (80% to 99% of cases)
- Deposits immunoreactive to beta-amyloid proteinHPOHP:0003791
- Very frequent (80% to 99% of cases)
- HallucinationsHPOHP:0000738
- Very frequent (80% to 99% of cases)
- HypertoniaHPOHP:0001276
- Very frequent (80% to 99% of cases)
- Language impairmentHPOHP:0002463
- Very frequent (80% to 99% of cases)
- Memory impairmentHPOHP:0002354
- Very frequent (80% to 99% of cases)
- MyoclonusHPOHP:0001336
- Very frequent (80% to 99% of cases)
- Neurodevelopmental abnormalityHPOHP:0012759
- Very frequent (80% to 99% of cases)
Show the remaining 14
- Neurofibrillary tanglesHPOHP:0002185
- Very frequent (80% to 99% of cases)
- ParkinsonismHPOHP:0001300
- Very frequent (80% to 99% of cases)
- SeizureHPOHP:0001250
- Very frequent (80% to 99% of cases)
- DisinhibitionHPOHP:0000734
- Frequent (30% to 79% of cases)
- Abnormality of mental functionHPOHP:0011446
- Occasional (5% to 29% of cases)
- Abnormality of visionHPOHP:0000504
- Occasional (5% to 29% of cases)
Genes
4 genes
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
Where it sits
- Narrower terms (14)
- Alzheimer disease 10
- Alzheimer disease 11
- Alzheimer disease 12
- Alzheimer disease 13
- Alzheimer disease 14
- Alzheimer disease 3
- Alzheimer disease 4
- Alzheimer disease 5
- Alzheimer disease 6
- Alzheimer disease 7
- Alzheimer disease 8
- Alzheimer disease type 1
- Alzheimer disease without neurofibrillary tangles
- Alzheimer disease, familial early-onset, with coexisting amyloid and prion pathology
Other names
2 names
Resolves to: early-onset autosomal dominant Alzheimer disease
- Also called
- early-onset familial autosomal dominant Alzheimer diseaseEOFAD