dystonia 25
Findings
No curated finding names dystonia 25 yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Autosomal dominant focal dystonia, DTY25 is a form of focal dystonia, characterized by cervical, laryngeal and hand-forearm dystonia.
Definition from the Mondo Disease Ontology (MONDO:0014033), read 2026-09-29. CC BY 4.0.
- Inheritance
- Autosomal dominant inheritance
- Onset and course
- Adult onset · Juvenile onset
HPO, annotations 2026-09-02
Features
8 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Focal dystoniaHPOHP:0004373
- Very frequent (80% to 99% of cases)
- Axial dystoniaHPOHP:0002530
- Frequent (30% to 79% of cases)
- Craniofacial dystoniaHPOHP:0012179
- Frequent (30% to 79% of cases)
- Laryngeal dystoniaHPOHP:0012049
- Frequent (30% to 79% of cases)
- Limb dystoniaHPOHP:0002451
- Frequent (30% to 79% of cases)
- Lingual dystoniaHPOHP:0031008
- Frequent (30% to 79% of cases)
- TorticollisHPO
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- GNALHGNC:4388
- Definitive · Ambry Genetics · Autosomal dominant · 2025
- Strong · Genomics England PanelApp · Autosomal dominant · 2021
- Strong · Labcorp Genetics (formerly Invitae) · Autosomal dominant · 2022
- Strong · PanelApp Australia · Autosomal dominant · 2025
- Supportive · Orphanet · Autosomal dominant · 2021
Where it sits
Other names
3 names
Resolves to: dystonia 25
- Also called
- dystonia type 25dystonic disorder caused by mutation in GNALGNAL dystonic disorder