distal myopathy, Welander type
Findings
No curated finding names distal myopathy, Welander type yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Welander distal myopathy (WDM) is a distal myopathy, characterized by weakness in the distal upper extremities, usually finger and wrist extensors which later progresses to all hand muscles and distal lower extremity, primarily in toe and ankle extensors.
Definition from the Mondo Disease Ontology (MONDO:0011466), read 2026-09-29. CC BY 4.0.
- Inheritance
- Autosomal dominant inheritance
- Onset and course
- Adult onset · Slowly progressive
HPO, annotations 2026-09-02
Features
14 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Distal upper limb muscle weaknessHPOHP:0008959
- Very frequent (80% to 99% of cases)
- EMG: myopathic abnormalitiesHPOHP:0003458
- Very frequent (80% to 99% of cases)
- Foot dorsiflexor weaknessHPOHP:0009027
- Very frequent (80% to 99% of cases)
- Intrinsic hand muscle atrophyHPOHP:0008954
- Very frequent (80% to 99% of cases)
- MyopathyHPOHP:0003198
- Very frequent (80% to 99% of cases)
- Weakness of long finger extensor musclesHPOHP:0009077
- Very frequent (80% to 99% of cases)
Show the remaining 2
- Distal amyotrophyHPOHP:0003693
- Distal muscle weaknessHPOHP:0002460
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- TIA1HGNC:11802
- Strong · Labcorp Genetics (formerly Invitae) · Autosomal dominant · 2018
- Supportive · Orphanet · Autosomal dominant · 2021
Where it sits
- A kind of
Other names
1 name
Resolves to: distal myopathy, Welander type
- Also called
- WDM