dilated cardiomyopathy 1FF
Findings
No curated finding names dilated cardiomyopathy 1FF yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A dilated cardiomyopathy that has material basis in mutation in the TNNI3 gene on chromosome 19q13.42.
Definition from the Mondo Disease Ontology (MONDO:0013211), read 2026-09-29. CC BY 4.0.
- Inheritance
- Autosomal dominant inheritance
- Onset and course
- Middle age onset · Juvenile onset · Young adult onset · Death in middle age
HPO, annotations 2026-09-02
Features
4 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Congestive heart failureHPOHP:0001635
- 4 of 4 reported patients
- Dilated cardiomyopathyHPOHP:0001644
- 2 of 2 reported patients
- Increased left ventricular end-diastolic volumeHPOHP:0033755
- 5 of 5 reported patients
- Severely reduced left ventricular ejection fractionHPOHP:0012666
- 4 of 5 reported patients
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- TNNI3HGNC:11947
- Strong · ClinGen · Autosomal dominant · 2026
- Strong · Labcorp Genetics (formerly Invitae) · Autosomal dominant · 2020
Where it sits
Other names
3 names
Resolves to: dilated cardiomyopathy 1FF
- Also called
- cardiomyopathy, dilated, type 1FfCMD1FFdilated cardiomyopathy type 1FF