dilated cardiomyopathy 1C
Findings
No curated finding names dilated cardiomyopathy 1C yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A dilated cardiomyopathy that has material basis in mutation in the LDB3 gene on chromosome 10q23.2.
Definition from the Mondo Disease Ontology (MONDO:0011094), read 2026-09-29. CC BY 4.0.
- Inheritance
- Autosomal dominant inheritance
- Onset and course
- Adult onset
HPO, annotations 2026-09-02
Features
5 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Dilated cardiomyopathyHPOHP:0001644
- 13 of 13 reported patients
- Increased left ventricular end-diastolic volumeHPOHP:0033755
- 10 of 13 reported patients
- Left ventricular hypertrophyHPOHP:0001712
- 8 of 13 reported patients
- Sudden cardiac deathHPOHP:0001645
- 3 of 13 reported patients
- Left bundle branch blockHPOHP:0011713
- 1 of 13 reported patients
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- LDB3HGNC:15710
- Strong · PanelApp Australia · Autosomal dominant · 2025
- Limited · ClinGen · Autosomal dominant · 2026
Where it sits
Other names
3 names
Resolves to: dilated cardiomyopathy 1C
- Also called
- cardiomyopathy, dilated, 1C, with or without LVNCcardiomyopathy, hypertrophic, 24dilated cardiomyopathy type 1C