cyclic hematopoiesis
Findings
No curated finding names cyclic hematopoiesis yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A hematologic disorder caused by a mutation in the ELANE (ELA2) gene; clinical manifestations include recurrent neutropenia with resultant susceptibility to infection leading to fever.
Definition from the Mondo Disease Ontology (MONDO:0008090), read 2026-09-29. CC BY 4.0.
- Inheritance
- Autosomal dominant inheritance
HPO, annotations 2026-09-02
Features
34 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Bone painHPOHP:0002653
- Very frequent (80% to 99% of cases)
- Cyclically decreased total neutrophil countHPOHP:0040289
- Very frequent (80% to 99% of cases)
- HeadacheHPOHP:0002315
- Very frequent (80% to 99% of cases)
- SinusitisHPOHP:0000246
- Very frequent (80% to 99% of cases)
- Cervical lymphadenopathyHPOHP:0025289
- Frequent (30% to 79% of cases)
- FatigueHPOHP:0012378
- Frequent (30% to 79% of cases)
- Gingivitis
Show the remaining 22
- Recurrent skin infectionsHPOHP:0001581
- Frequent (30% to 79% of cases)
- Recurrent tonsillitisHPOHP:0011110
- Frequent (30% to 79% of cases)
- Respiratory tract infectionHPOHP:0011947
- Frequent (30% to 79% of cases)
- Tooth abscessHPOHP:0030757
- Frequent (30% to 79% of cases)
- Abdominal painHPOHP:0002027
- Occasional (5% to 29% of cases)
- Atrophy of alveolar ridgesHPOHP:0006308
- Occasional (5% to 29% of cases)
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- ELANEHGNC:3309
- Strong · Labcorp Genetics (formerly Invitae) · Autosomal dominant · 2022
- Supportive · Orphanet · Autosomal dominant · 2021
Where it sits
Other names
6 names
Resolves to: cyclic hematopoiesis
- Also called
- CHCNcyclic agranulocytosisdysplasia, myelocytic periodicneutropenia, cyclicperiodic neutropenia