Cushing disease due to pituitary adenoma
MONDO:0009050Mondo
Findings
No curated finding names Cushing disease due to pituitary adenoma yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A form of adrenocorticotropic hormone (ACTH)-dependent Cushing syndrome, an endogenous Cushing syndrome (CS), characterized by chronic over-secretion of adrenocorticotropic hormone (ACTH) due to a pituitary corticotroph adenoma.
Definition from the Mondo Disease Ontology (MONDO:0009050), read 2026-09-29. CC BY 4.0.
Features
64 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Increased circulating cortisol levelHPOHP:0003118
- Very frequent (80% to 99% of cases)
- Increased urinary cortisol levelHPOHP:0012030
- Very frequent (80% to 99% of cases)
- Paradoxical increased cortisol secretion on dexamethasone suppression testHPOHP:0003466
- Very frequent (80% to 99% of cases)
- Pituitary corticotropic cell adenomaHPOHP:0008291
- Very frequent (80% to 99% of cases)
- Abdominal obesityHPOHP:0012743
- Frequent (30% to 79% of cases)
- Abnormality of the cardiovascular systemHPOHP:0001626
- Frequent (30% to 79% of cases)
- AcneHPOHP:0001061
- Frequent (30% to 79% of cases)
- Adrenal hyperplasiaHPOHP:0008221
- Frequent (30% to 79% of cases)
- AmenorrheaHPOHP:0000141
- Frequent (30% to 79% of cases)
- Atypical behaviorHPOHP:0000708
- Frequent (30% to 79% of cases)
- Bruising susceptibilityHPOHP:0000978
- Frequent (30% to 79% of cases)
- Capillary fragilityHPOHP:0025017
- Frequent (30% to 79% of cases)
Show the remaining 52
- Decreased total eosinophil countHPOHP:0031891
- Frequent (30% to 79% of cases)
- Decreased total lymphocyte countHPOHP:0001888
- Frequent (30% to 79% of cases)
- Diabetes mellitusHPOHP:0000819
- Frequent (30% to 79% of cases)
- Dorsocervical fat padHPOHP:0025383
- Frequent (30% to 79% of cases)
- Emotional labilityHPOHP:0000712
- Frequent (30% to 79% of cases)
- Fatiguable weakness of proximal limb musclesHPOHP:0030200
- Frequent (30% to 79% of cases)
Where it sits
Other names
12 names
Resolves to: Cushing disease due to pituitary adenoma
- Also called
- ACTH producing pituitary adenomacorticotroph pituitary adenomaCushing diseaseCushing disease, pituitaryCushing's diseasePITA4pituitary adenoma 4, ACTH-secretingpituitary adenoma 4, ACTH-secreting, somaticpituitary adenoma, ACTH-secretingpituitary corticotroph micro-adenomapituitary dependent Cushing syndromepituitary-dependent Cushing syndrome