Cronkhite-Canada syndrome
MONDO:0008283Mondo
Findings
No curated finding names Cronkhite-Canada syndrome yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Cronkhite-Canada syndrome (CCS) is a rare gastrointestinal (GI) polyposis syndrome characterized by the association of non-hereditary GI polyposis with the cutaneous triad of alopecia, nail changes and hyperpigmentation.
Definition from the Mondo Disease Ontology (MONDO:0008283), read 2026-09-29. CC BY 4.0.
Features
33 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Abnormal fingernail morphologyHPOHP:0001231
- Very frequent (80% to 99% of cases)
- Abnormal skin pigmentationHPOHP:0001000
- Very frequent (80% to 99% of cases)
- AlopeciaHPOHP:0001596
- Very frequent (80% to 99% of cases)
- DiarrheaHPOHP:0002014
- Very frequent (80% to 99% of cases)
- Dystrophic fingernailsHPOHP:0008391
- Very frequent (80% to 99% of cases)
- Dystrophic toenailHPOHP:0001810
- Very frequent (80% to 99% of cases)
- Generalized hyperpigmentationHPOHP:0007440
- Very frequent (80% to 99% of cases)
- Hamartomatous polyposisHPOHP:0004390
- Very frequent (80% to 99% of cases)
- Hypoplastic toenailsHPOHP:0001800
- Very frequent (80% to 99% of cases)
- Intestinal polyposisHPOHP:0200008
- Very frequent (80% to 99% of cases)
- MalabsorptionHPOHP:0002024
- Very frequent (80% to 99% of cases)
- Patchy alopeciaHPOHP:0002232
- Very frequent (80% to 99% of cases)
Show the remaining 21
- Abdominal painHPOHP:0002027
- Frequent (30% to 79% of cases)
- Abnormality of the vasculatureHPOHP:0002597
- Frequent (30% to 79% of cases)
- AnemiaHPOHP:0001903
- Frequent (30% to 79% of cases)
- AnorexiaHPOHP:0002039
- Frequent (30% to 79% of cases)
- Aplasia/Hypoplasia of the eyebrowHPOHP:0100840
- Frequent (30% to 79% of cases)
- CachexiaHPOHP:0004326
- Frequent (30% to 79% of cases)
Where it sits
Other names
3 names
Resolves to: Cronkhite-Canada syndrome
- Also called
- gastric Cronkhite Canada polyposisgastrointestinal polyposis-ectodermal changes syndromegastrointestinal polyposis-skin pigmentation-alopecia-fingernail changes syndrome