craniorachischisis
MONDO:0018969Mondo
Findings
No curated finding names craniorachischisis yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Craniorachischisis is the most severe form of neural tube defect in which both the brain and spinal cord remain open to varying degrees. It is a very rare congenital malformation of the central nervous system.
Definition from the Mondo Disease Ontology (MONDO:0018969), read 2026-09-29. CC BY 4.0.
Features
9 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- AnencephalyHPOHP:0002323
- Very frequent (80% to 99% of cases)
- Cervical spina bifidaHPOHP:0005857
- Very frequent (80% to 99% of cases)
- MyelomeningoceleHPOHP:0002475
- Very frequent (80% to 99% of cases)
- Spinal dysraphismHPOHP:0010301
- Very frequent (80% to 99% of cases)
- Anal atresiaHPOHP:0002023
- Occasional (5% to 29% of cases)
- Bifid sternumHPOHP:0010309
- Occasional (5% to 29% of cases)
- Congenital diaphragmatic herniaHPOHP:0000776
- Occasional (5% to 29% of cases)
- OmphaloceleHPOHP:0001539
- Occasional (5% to 29% of cases)
- SirenomeliaHPOHP:0010497
- Occasional (5% to 29% of cases)
Where it sits
Other names
2 names
Resolves to: craniorachischisis
- Also called
- cranial rachischisiscraniorachischisis (disease)