congenital syphilis
MONDO:0005714Mondo
Findings
No curated finding names congenital syphilis yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A life-threatening bacterial infection of the newborn caused by Treponema pallidum. It is transmitted to the infant from a mother with syphilis through the placenta during pregnancy. Signs and symptoms include irritability, fever, failure to thrive, saddle nose, cutaneous rash, and pneumonia.
Definition from the Mondo Disease Ontology (MONDO:0005714), read 2026-09-29. CC BY 4.0.
Features
46 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Extramedullary hematopoiesisHPOHP:0001978
- Frequent (30% to 79% of cases)
- HepatosplenomegalyHPOHP:0001433
- Frequent (30% to 79% of cases)
- Hydrops fetalisHPOHP:0001789
- Frequent (30% to 79% of cases)
- Large placentaHPOHP:0006267
- Frequent (30% to 79% of cases)
- Maculopapular exanthemaHPOHP:0040186
- Frequent (30% to 79% of cases)
- OsteochondrosisHPOHP:0040188
- Frequent (30% to 79% of cases)
- PeriostitisHPOHP:0040165
- Frequent (30% to 79% of cases)
- PetechiaeHPOHP:0000967
- Frequent (30% to 79% of cases)
- Premature birthHPOHP:0001622
- Frequent (30% to 79% of cases)
- PurpuraHPOHP:0000979
- Frequent (30% to 79% of cases)
- ThrombocytopeniaHPOHP:0001873
- Frequent (30% to 79% of cases)
- AnemiaHPOHP:0001903
- Occasional (5% to 29% of cases)
Show the remaining 34
- CataractHPOHP:0000518
- Occasional (5% to 29% of cases)
- ChorioretinitisHPOHP:0012424
- Occasional (5% to 29% of cases)
- CSF pleocytosisHPOHP:0012229
- Occasional (5% to 29% of cases)
- DiarrheaHPOHP:0002014
- Occasional (5% to 29% of cases)
- Frontal bossingHPOHP:0002007
- Occasional (5% to 29% of cases)
- GlaucomaHPOHP:0000501
- Occasional (5% to 29% of cases)
Where it sits
- A kind of
- Narrower terms (2)
Other names
2 names
Resolves to: congenital syphilis
- Also called
- mother-to-child transmission of syphilisMTCT of syphilis