congenital megacalycosis
Findings
No curated finding names congenital megacalycosis yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Congenital megacalycosis is a rare renal malformation, characterized by non-obstructive dilation of the renal calyces as well as an increased calyceal number (12-20), with a normal renal pelvis, ureter, and bladder. It may be unilateral or bilateral and is usually asymptomatic unless complicated by nephrolithiasis and urinary tract infection.
Definition from the Mondo Disease Ontology (MONDO:0019639), read 2026-09-29. CC BY 4.0.
Features
9 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Dilatation of renal calicesHPOHP:0100581
- Obligate (100% of cases)
- Abnormal renal physiologyHPOHP:0012211
- Frequent (30% to 79% of cases)
- Enlarged kidneyHPOHP:0000105
- Frequent (30% to 79% of cases)
- HematuriaHPOHP:0000790
- Frequent (30% to 79% of cases)
- HydronephrosisHPOHP:0000126
- Frequent (30% to 79% of cases)
- Recurrent urinary tract infectionsHPOHP:0000010
- Frequent (30% to 79% of cases)
- Renal cystHPOHP:0000107
- Frequent (30% to 79% of cases)
- Tubulointerstitial nephritisHPOHP:0001970
- Frequent (30% to 79% of cases)
- Kidney stoneHPOHP:0000787
- Occasional (5% to 29% of cases)
Reported absent (1)
- Ureteral obstructionHPOHP:0006000
Where it sits
- A kind of
- Narrower terms (2)