congenital hypothyroidism due to transplacental passage of maternal TSH-binding inhibitory antibodies
MONDO:0019857Mondo
Findings
No curated finding names congenital hypothyroidism due to transplacental passage of maternal TSH-binding inhibitory antibodies yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Congenital hypothyroidism due to transplacental passage of maternal thyroid-stimulating hormone (TSH)-binding inhibitory antibodies is a type of transient congenital hypothyroidism, a thyroid hormone deficiency that is not permanent.
Definition from the Mondo Disease Ontology (MONDO:0019857), read 2026-09-29. CC BY 4.0.
Features
19 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Autoimmune antibody positivityHPOHP:0030057
- Very frequent (80% to 99% of cases)
- Abnormality of thyroid physiologyHPOHP:0002926
- Frequent (30% to 79% of cases)
- ConstipationHPOHP:0002019
- Frequent (30% to 79% of cases)
- Decreased circulating T4 concentrationHPOHP:0031507
- Frequent (30% to 79% of cases)
- Decreased thyroid-stimulating hormone levelHPOHP:0031098
- Frequent (30% to 79% of cases)
- Dry skinHPOHP:0000958
- Frequent (30% to 79% of cases)
Show the remaining 7
- Abnormal circulating thyroglobulin concentrationHPOHP:0025483
- Occasional (5% to 29% of cases)
- Anti-thyroid peroxidase antibody positivityHPOHP:0025379
- Occasional (5% to 29% of cases)
- Coarse facial featuresHPOHP:0000280
- Occasional (5% to 29% of cases)
- Conjugated hyperbilirubinemiaHPOHP:0002908
- Occasional (5% to 29% of cases)
- Moon faciesHPOHP:0500011
- Occasional (5% to 29% of cases)
- Neonatal hypotoniaHPOHP:0001319
- Occasional (5% to 29% of cases)