combined deficiency of factor V and factor VIII
Findings
No curated finding names combined deficiency of factor V and factor VIII yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Combined deficiency of factor V and factor VIII is an inherited bleeding disorder due to the reduction in activity and antigen levels of both factor V (FV) and factor VIII (FVIII) and characterized by mild-to-moderate bleeding symptoms.
Definition from the Mondo Disease Ontology (MONDO:0018175), read 2026-09-29. CC BY 4.0.
Features
18 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Prolonged partial thromboplastin timeHPOHP:0003645
- Very frequent (80% to 99% of cases)
- Prolonged prothrombin timeHPOHP:0008151
- Very frequent (80% to 99% of cases)
- Reduced coagulation factor V activityHPOHP:0003225
- Very frequent (80% to 99% of cases)
- Reduced factor VIII activityHPOHP:0003125
- Very frequent (80% to 99% of cases)
- Bleeding with minor or no traumaHPOHP:0011889
- Frequent (30% to 79% of cases)
- Bruising susceptibilityHPOHP:0000978
- Frequent (30% to 79% of cases)
- EpistaxisHPOHP:0000421
- Frequent (30% to 79% of cases)
- Gingival bleedingHPOHP:0000225
- Frequent (30% to 79% of cases)
- Prolonged bleeding after dental extractionHPOHP:0006298
- Frequent (30% to 79% of cases)
- Prolonged bleeding following circumcisionHPOHP:0030137
- Frequent (30% to 79% of cases)
- Gastrointestinal hemorrhageHPOHP:0002239
- Occasional (5% to 29% of cases)
- HematuriaHPOHP:0000790
- Occasional (5% to 29% of cases)
Show the remaining 6
- Intracranial hemorrhageHPOHP:0002170
- Occasional (5% to 29% of cases)
- Joint hemorrhageHPOHP:0005261
- Occasional (5% to 29% of cases)
- MenorrhagiaHPOHP:0000132
- Occasional (5% to 29% of cases)
- Prolonged bleeding after surgeryHPOHP:0004846
- Occasional (5% to 29% of cases)
- HyperlipidemiaHPOHP:0003077
- Very rare (1% to 4% of cases)
- HyperuricemiaHPOHP:0002149
- Very rare (1% to 4% of cases)
Genes
2 genes
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
Where it sits
Other names
4 names
Resolves to: combined deficiency of factor V and factor VIII
- Also called
- combined deficiency of factor V and factor type VIIIF5F8Dfamilial multiple coagulation factor deficiencyFV and FVIII combined deficiency