colorectal cancer, susceptibility to, 10
Findings
No curated finding names colorectal cancer, susceptibility to, 10 yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Any colorectal cancer in which the cause of the disease is a mutation in the POLD1 gene.
Definition from the Mondo Disease Ontology (MONDO:0012953), read 2026-09-29. CC BY 4.0.
- Inheritance
- Autosomal dominant inheritance
- Onset and course
- Adult onset
HPO, annotations 2026-09-02
Features
3 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Colorectal polyposisHPOHP:0200063
- Endometrial carcinomaHPOHP:0012114
- Hereditary nonpolyposis colorectal carcinomaHPOHP:0006716
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- POLD1HGNC:9175
- Strong · Genomics England PanelApp · Autosomal dominant · 2020
- Strong · Labcorp Genetics (formerly Invitae) · Autosomal dominant · 2022
- Moderate · Ambry Genetics · Autosomal dominant · 2023
Where it sits
- A kind of
Other names
3 names
Resolves to: colorectal cancer, susceptibility to, 10
- Also called
- colorectal cancer caused by mutation in POLD1colorectal cancer, susceptibility to, type 10POLD1 colorectal cancer