cold agglutinin disease
MONDO:0018922Mondo
Findings
No curated finding names cold agglutinin disease yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Cold agglutinin disease is a type of autoimmune hemolytic anemia defined by the presence of cold autoantibodies (autoantibodies which are active at temperatures below 30B0C).
Definition from the Mondo Disease Ontology (MONDO:0018922), read 2026-09-29. CC BY 4.0.
Features
14 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- ArthralgiaHPOHP:0002829
- Very frequent (80% to 99% of cases)
- AutoimmunityHPOHP:0002960
- Very frequent (80% to 99% of cases)
- FatigueHPOHP:0012378
- Very frequent (80% to 99% of cases)
- Hemolytic anemiaHPOHP:0001878
- Very frequent (80% to 99% of cases)
- Muscle weaknessHPOHP:0001324
- Very frequent (80% to 99% of cases)
- PallorHPOHP:0000980
- Very frequent (80% to 99% of cases)
- Abnormal urinary colorHPOHP:0012086
- Occasional (5% to 29% of cases)
- Back painHPOHP:0003418
- Occasional (5% to 29% of cases)
- DiarrheaHPOHP:0002014
- Occasional (5% to 29% of cases)
- HeadacheHPOHP:0002315
- Occasional (5% to 29% of cases)
- HepatomegalyHPOHP:0002240
- Occasional (5% to 29% of cases)
- LymphadenopathyHPOHP:0002716
- Occasional (5% to 29% of cases)
Show the remaining 2
- Nausea and vomitingHPOHP:0002017
- Occasional (5% to 29% of cases)
- SplenomegalyHPOHP:0001744
- Occasional (5% to 29% of cases)
Where it sits
Other names
4 names
Resolves to: cold agglutinin disease
- Also called
- CADCASchronic cold agglutinin diseasecold agglutinin syndrome