Cogan syndrome
Findings
No curated finding names Cogan syndrome yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Cogan syndrome (CS) is a rare autoimmune disorder of unknown origin characterized by inflammatory ocular disease (mainly interstitial keratitis) and vestibulo-auditory manifestations (mainly acute onset hearing loss, tinnitus and vertigo), in the setting of a negative work-up for syphilis, with a variable risk of developing into a systemic disease. Systemic manifestations may occur in more than 70% of cases.
Definition from the Mondo Disease Ontology (MONDO:0015453), read 2026-09-29. CC BY 4.0.
Features
20 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Abnormal vestibular functionHPOHP:0001751
- Very frequent (80% to 99% of cases)
- KeratitisHPOHP:0000491
- Very frequent (80% to 99% of cases)
- PhotophobiaHPOHP:0000613
- Very frequent (80% to 99% of cases)
- Reduced visual acuityHPOHP:0007663
- Very frequent (80% to 99% of cases)
- TinnitusHPOHP:0000360
- Very frequent (80% to 99% of cases)
- VertigoHPOHP:0002321
- Very frequent (80% to 99% of cases)
- AnemiaHPO
Show the remaining 8
- Aortic regurgitationHPOHP:0001659
- Occasional (5% to 29% of cases)
- BlindnessHPOHP:0000618
- Occasional (5% to 29% of cases)
- ConjunctivitisHPOHP:0000509
- Occasional (5% to 29% of cases)
- EpiscleritisHPOHP:0100534
- Occasional (5% to 29% of cases)
- Large vessel vasculitisHPOHP:0005310
- Occasional (5% to 29% of cases)
- ScleritisHPOHP:0100532
- Occasional (5% to 29% of cases)